When convicted double murderer Sarah Pender escapes from a maximum-security prison in Indiana, a nationwide manhunt is immediately launched. Charged alongside her former boyfriend, who pled guilty, for the murder of a young couple, Pender has vanished, igniting fear, fascination, and a relentless pursuit that stretches across state lines. "Girl on the Run: The Hunt for America's Most Wanted Woman" unfolds as a tense, real-life cat-and-mouse chase, following U.S. Marshals as they race to track down Pender before she disappears for good. As authorities close in, Pender relies on a network of trusted ex-cons and a well to do new boyfriend, Tom, to help her evade capture. Even after Tom realizes who Sarah is while watching an episode of 'America's Most Wanted' together, he continues to help her constantly stay one step ahead while the pressure mounts and the police close in.